Synthesis and Biological Evaluation of 2,4-Diaminoquinazolines as Potential Antitumor Agents
Table 1
Cytotoxic activity (IC50, μg/ml) of 2,4-diaminoquinazoline derivatives against human cancer cell lines.a
No.
MCF7
HCT 116
HePG2
HFB4
5-FU
5.4 ± 0.20
5.3 ± 0.18
7.9 ± 0.21
8.8 ± 0.52
4a
34.4 ± 3.41
41.4 ± 3.62
48.9 ± 3.60
31.8 ± 3.15
4b
12.7 ± 1.32
36.9 ± 3.04
40.5 ± 3.51
20.4 ± 1.98
4c
11.1±1.10
10.8±0.86
12.0±0.97
10.8±1.24
4d
13.6 ± 1.65
19.4 ± 1.50
18.0 ± 1.72
13.7 ± 1.20
5a
27.4 ± 1.97
32.8 ± 2.89
31.2 ± 3.43
30.1 ± 3.36
5b
10.9±1.03
9.1±0.85
10.4±1.11
9.9±1.07
5c
16.3 ± 1.56
17.4 ± 1.32
26.2 ± 2.32
15.7 ± 1.61
5d
71.8 ± 4.74
81.4 ± 5.37
88.9 ± 6.41
66.8 ± 4.19
aIC50: The concentration that causes 50% of cell proliferation inhibition. The data are expressed as the means ± SD of at least three separate experiments.
