Research Article

Synthesis and Biological Evaluation of 2,4-Diaminoquinazolines as Potential Antitumor Agents

Table 2

DNA/methyl green colorimetric assay of the DNA-binding compounds.

DNA-active compoundsDNA/methyl green (IC50, μg/ml)a

4a64 ± 4
4b75±5
4d81±5
5a79±4
5c70±4
5d61 ± 3

aIC50 values represent the concentration (mean ± SD, n = 3–5 separate determinations) required for a 50% decrease in the initial absorbance of the DNA/methyl green solution.