Research Article
Development and Evaluation of a Novel Polymer Drug Delivery System Using Cromolyn-Polyamides-Disulfide using Response Surface Design
Table 8
Comparative results between observed and predicted response values of variables of optimized formulation.
| | Concentrations | Experimental response | Predicted values | Observed values | Bias (%) |
| | Drug (0.2 gm) | LE (%) | 55.1% | 58.0% | 5.3% | | FeCl3 (0.3 gm) | | Polymer (0.05 gm) | Zeta potential (mV) | 28.1 mV | 32.2 mV | 14.6% | | pH = 2.2 |
| | Drug (0.121 gm) | LE (%) | 23.2% | 22.0% | −5.2% | | FeCl3 (0.6926 gm) | | Polymer (0.121 gm) | Zeta potential (mV) | 15.3 mV | 13.3 mV | −13.1% | | pH = 3.1 |
| | Drug (0.2 gm) | LE (%) | 39.3% | 37.7% | −4.1% | | FeCl3 (0.3 gm) | | Polymer (0.2 gm) | Zeta potential (mV) | 29.5 mV | 23.9 mV | −19.0% | | pH = 2.2 |
| | % bias was calculated as (observed value – predicted value/predicted value) ×100 |
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