Research Article
Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies
Table 1
COX-2 inhibitory potentials of the tested compounds (A–D).
| | Compounds | Concentration (µg/ml) | %Inhibition (mean ± SEM) | IC50 (µg/ml) |
| | A | 1000
500
250
125
62.5
31.25 | 54.43 ± 1.50
47.97 ± 1.25
41.87 ± 0.65
33.17 ± 0.53
24.17 ± 0.66
15.60 ± 2.03 | 582 |
| | B | 1000
500
250
125
62.5
31.25 | 57.39 ± 0.49
51.00 ± 0.00
41.33 ± 0.33
34.33 ± 0.66
22.17 ± 0.53
11.48 ± 0.23 | 475 |
| | C | 1000
500
250
125
62.5
31.25 | 49.76 ± 0.61
41.13 ± 0.80
34.48 ± 0.23
27.67 ± 0.94
21.37 ± 0.56
17.05 ± 0.13 | 1170 |
| | D | 1000
500
250
125
62.5
31.25 | 81.70 ± 0.67
74.90 ± 0.57
65.73 ± 0.84
59.77 ± 0.82
52.13 ± 0.70
47.90 ± 0.78 | 43 |
| | Celecoxib | 1000
500
250
125
62.5
31.25 | 85.47 ± 0.59
78.60 ± 0.73
73.32 ± 0.68
65.42 ± 0.46
59.17 ± 0.66
53.37 ± 0.72 | 22 |
|
|
