Research Article
Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies
Table 2
5-LOX inhibitory potentials of the compounds.
| | Compounds | Concentration (µg/ml) | %Inhibition (mean ± SEM) | IC50 (µg/ml) |
| | A | 1000
500
250
125
62.5
31.25 | 49.66 ± 0.88
45.50 ± 0.44
41.00 ± 2.64
37.00 ± 0.00
31.33 ± 0.33
24.33 ± 0.66 | 930 |
| | B | 1000
500
250
125
62.5
31.25 | 57.00 ± 1.52
52.66 ± 1.20
45.00 ± 0.16
39.16 ± 1.01
32.83 ± 0.92
25.16 ± 0.44 | 420 |
| | C | 1000
500
250
125
62.5
31.25 | 44.33 ± 1.76
35.16 ± 1.01
29.66 ± 0.88
22.50 ± 0.28
11.00 ± 0.00
05.16 ± 0.60 | ˃1000 |
| | D | 1000
500
250
125
62.5
31.25 | 72.50 ± 1.04
65.58 ± 0.69
56.37 ± 0.65
49.44 ± 0.58
42.16 ± 0.60
37.37 ± 0.54 | 120 |
| | Zileuton | 1000
500
250
125
62.5
31.25 | 77.00 ± 0.16
71.66 ± 1.20
65.33 ± 0.33
57.50 ± 0.44
51.00 ± 0.57
44.66 ± 0.88 | 52 |
|
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