Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies

Table 3

Percentage inhibitions of compounds in the carrageenan-induced paw edema.

Treatment	Dose (mg/kg)	Percent inhibition of paw edema
		1 h	2 h	3 h	4 h	5 h
Vehicle	—	7.662 ± 3.75	7.392 ± 2.48	11.41 ± 3.07	14.45 ± 1.57	7.307 ± 3.20
Aspirin	100	47.54 ± 4.12	54.63 ± 1.47	53.26 ± 1.36	56.92 ± 2.95	57.64 ± 1.55
A	25	14.70 ± 2.65 ^ns	22.44 ± 1.54	24.56 ± 2.35	28.39 ± 2.48	26.25 ± 2.63
	50	20.35 ± 2.21	24.54 ± 4.59	26.58 ± 2.59	29.78 ± 2.60	27.66 ± 3.75
	100	31.29 ± 3.08	31.36 ± 2.69	28.72 ± 1.69	37.01 ± 2.97	33.55 ± 2.44
B	25	34.68 ± 4.79	36.35 ± 3.13	22.55 ± 2.44	33.84 ± 2.56	33.55 ± 2.44
	50	37.45 ± 2.56	37.68 ± 3.28	24.70 ± 1.90	32.32 ± 2.52	34.57 ± 2.34
	100	41.33 ± 3.27 ^ns	41.86 ± 1.19	36.78 ± 2.60	40.30 ± 1.18	43.27 ± 2.57
C	25	7.07 ± 2.33 ^ns	17.85 ± 2.23 ^ns	19.19 ± 2.23 ^ns	28.39 ± 3.36	26.11 ± 3.58
	50	20.11 ± 3.58	21.92 ± 4.38	24.97 ± 3.61	31.30 ± 3.20	27.66 ± 3.75
	100	29.26 ± 1.36	36.88 ± 1.56	34.09 ± 1.24	35.74 ± 2.60	33.55 ± 2.44
D	25	42.85 ± 3.27	43.83 ± 2.79	39.87 ± 3.24	39.04 ± 3.28	38.80 ± 1.85
	50	44.11 ± 3.58	45.28 ± 2.80	41.75 ± 3.76	42.84 ± 2.93	40.07 ± 2.33
	100	45.77 ± 2.69	51.05 ± 3.02	54.36 ± 2.59	55.92 ± 2.95	49.25 ± 2.53

Percent inhibition produced by synthesized compounds (25, 50, and 100 mg/kg) of the carrageenan-induced paw edema model in mice. Each percentage point represents the mean ± SEM for a group of 8 mice. Data were analyzed by two-way repeated measures ANOVA followed by Bonferroni’s post hoc test. Asterisks show significant values from control (vehicle). , , and . n.s, nonsignificant; n = 8 mice per group.