Anti-Inflammatory Potentials of β-Ketoester Derivatives of N-Ary Succinimides: In Vitro, In Vivo, and Molecular Docking Studies

Table 4

Percentage inhibition of compounds in the arachidonic acid-induced ear edema.

Treatment	Dose (mg/kg)	Percent inhibition of ear edema
		10 min	15 min	30 min	45 min	60 min
Vehicle	—	8.75 ± 0.56	8.62 ± 1.79	13.33 ± 2.19	16.21 ± 2.86	8.66 ± 3.18
Nimesulide	50	58.66 ± 4.63	60.33 ± 2.33	63.67 ± 1.76	66.00 ± 2.52	67.41 ± 3.04
A	25	30.54 ± 2.34	33.18 ± 3.87	30.47 ± 3.01	26.39 ± 2.86	19.51 ± 2.83
	50	34.04 ± 4.59	36.33 ± 2.91	34.72 ± 2.48	29.57 ± 2.31	22.81 ± 2.51
	100	37.22 ± 1.58	39.15 ± 1.16	37.93 ± 1.16	34.54 ± 1.27	25.25 ± 3.89
B	25	33.70 ± 3.35	34.67 ± 2.27	37.53 ± 1.56	28.43 ± 1.48	26.76 ± 1.86
	50	39.92 ± 2.87	38.84 ± 1.98	41.03 ± 2.88	0.58 ± 2.54	29.57 ± 2.31
	100	43.25 ± 3.09	45.15 ± 1.67	48.36 ± 2.87	36.02 ± 3.54	34.54 ± 0.64
C	25	18.57 ± 2.54^ns	21.85 ± 4.05	22.25 ± 2.90 ^ns	20.88 ± 2.45 ^ns	14.95 ± 1.95 ^ns
	50	21.66 ± 3.12	23.36 ± 2.64	25.55 ± 1.55	23.33 ± 1.20 ^ns	21.73 ± 2.37
	100	25.69 ± 1.80	27.40 ± 3.00	29.33 ± 3.18	26.02 ± 3.89 ^ns	22.88 ± 2.24
D	25	46.44 ± 2.74	51.07 ± 2.91	53.14 ± 1.03	52.33 ± 1.85	55.69 ± 2.25
	50	51.63 ± 0.52	54.32 ± 3.61	57.45 ± 2.56	55.77 ± 2.88	61.25 ± 1.78
	100	54.85 ± 2.18	57.23 ± 1.75	60.11 ± 4.79	58.14 ± 2.92	63.81 ± 2.24

Percent inhibition produced by synthesized compounds (25, 50, and 100 mg/kg) of the arachidonic acid-induced ear edema model in mice. Each percentage point embodies the mean ± SEM for a group of 8 mice. Data were analyzed by two-way repeated measures ANOVA pursued by Bonferroni’s post hoc test. , , and . n.s, nonsignificant; n = 8 mice per group.