Validated UPLC-MS/MS Method for Determination of Futibatinib and Its Pharmacokinetics in Beagle Dogs

Table 3

The stability of futibatinib in the beagle plasma (n = 6).

Added (ng/mL)	Room temperature, 12 h		Autosampler 4°C, 12 h		Three freeze-thaw		−20°C, 4 weeks
	RSD (%)	RE (%)	RSD (%)	RE (%)	RSD (%)	RE (%)	RSD (%)	RE (%)
1.0	7.85	−4.17	8.89	−2.50	8.41	0.50	9.68	−2.00
10	10.41	−3.67	8.86	−1.62	5.87	4.82	10.47	−0.68
75	2.58	0.20	6.45	0.59	6.38	−1.67	3.11	0.94