Validated UPLC-MS/MS Method for Determination of Futibatinib and Its Pharmacokinetics in Beagle Dogs

Table 4

Pharmacokinetic parameters of futibatinib after 0.67 mg/kg oral administration to 6 beagle dogs.

Parameters	Futibatinib
t 1/2 (h)	3.75 ± 1.08
T max (h)	1.50 ± 0.45
C max (ng/mL)	44.47 ± 10.02
MRT0⟶t (h)	4.53 ± 0.62
MRT0⟶∞ (h)	5.21 ± 0.63
Vz/F (L/kg)	28.61 ± 7.68
CLz/F (L/h)	5.35 ± 0.55
AUC0⟶t (ng·h/mL)	124.51 ± 13.38
AUC0⟶∞ (ng·h/mL)	126.43 ± 14.26