An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Reactivity descriptor</td><td class="align_center">Reactivity descriptor energy (a.u.)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Electron affinity</td><td class="align_center">0.0354</td></tr><tr><td class="align_left">Ionization potential</td><td class="align_center">0.2129</td></tr><tr><td class="align_left">Global hardness</td><td class="align_center">0.0887</td></tr><tr><td class="align_left">Softness</td><td class="align_center">5.637</td></tr><tr><td class="align_left">Electronegativity</td><td class="align_center">0.1241</td></tr><tr><td class="align_left">Electrophilicity index</td><td class="align_center">0.0868</td></tr><tr><td class="align_left">HOMO energy</td><td class="align_center">−0.2126</td></tr><tr><td class="align_left">LUMO energy</td><td class="align_center">−0.0354</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>The reactivity descriptors of tofacitinib citrate compounds.</div>

Journal of Chemistry

tab4

Table 4

Table 4: An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study 