Simultaneous Determination of Six Components in Beagle Dog Plasma by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study of Three Different Yuanhu Zhitong Preparations

Table 2

Optimized MS/MS transitions, cone and collision energy of the analytes and internal standards.

Compound	Parent ion (m/z)	Daughter ion (m/z)	Cone (V)	CE (V)
Cde	370.2	192.0	50	28
Thp	356.2	192.1	48	26
Thb	340.1	176.0	44	24
Bcin	335.0	317.0	14	6
Thc	324.0	176.0	44	26
Bcol	317.0	232.9	32	12
Is	285.1	86.0	26	16