Simultaneous Determination of Six Components in Beagle Dog Plasma by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study of Three Different Yuanhu Zhitong Preparations

Table 4

The regression equation, retention time, linear ranges, and LLOQs of the six analytes in dog plasma.

Compound name	Regression equation ( = 1/χ^2)	r	Retention time (min)	Linear range (ng/mL)	LLOQ (ng/mL)
Cde	y = 0.27x − 0.02	0.9972	6.58	0.2–40 ng/mL	0.2
Thp	y = 0.45x − 0.02	0.9962	6.17	0.1–20 ng/mL	0.1
Thb	y = 0.65x − 0.001	0.9928	6.49	0.1–20 ng/mL	0.1
Bcin	y = 0.05x + 0.03	0.9976	7.11	1–200 ng/mL	1
Thc	y = 0.41x − 0.01	0.9926	6.28	0.1–20 ng/mL	0.1
Bcol	y = 0.18x − 0.02	0.9926	7.11	0.2–40 ng/mL	0.2