Simultaneous Determination of Six Components in Beagle Dog Plasma by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study of Three Different Yuanhu Zhitong Preparations
Table 8
PK parameters of the six analytes after oral administration of YHZT OL, YHZT DT, and YHZT DP (mean ± SD, n = 6).
Analyte
Group
Tmax (h)
Cmax (NG/ML)
T1/2 (h)
AUC0-t (NG H/ML)
MRT0-t (h)
Vd (ML/KG)
CL (ML/H/KG)
Cde
YHZT OL
0.44 ± 0.17
36.75 ± 12.67
15.96 ± 6.24
74.96 ± 20.43
7.05 ± 1.54
67.93 ± 39.84
2.83 ± 0.67
YHZT DT
0.83 ± 0.62
18.78 ± 10.85
22.47 ± 6.57
65.94 ± 17.18
11.06 ± 1.25
123.43 ± 44.49
3.84 ± 1.13
YHZT DP
0.56 ± 0.17
30.77 ± 10.80
26.86 ± 11.17
92.14 ± 24.83
12.00 ± 2.45
59.50 ± 20.14
1.64 ± 0.58
Thp
YHZT OL
0.42 ± 0.20
80.83 ± 31.40
7.81 ± 0.50
254.31 ± 82.50
7.30 ± 1.37
11.42 ± 3.98
1.01 ± 0.34
YHZT DT
1.33 ± 1.30
45.70 ± 20.34
7.94 ± 0.67
179.81 ± 51.98
7.69 ± 1.67
11.15 ± 4.24
0.96 ± 0.31
YHZT DP
0.61 ± 0.25
52.50 ± 15.23
7.55 ± 2.63
172.35 ± 62.79
5.23 ± 2.64
12.01 ± 6.07
1.07 ± 0.40
Thb
YHZT OL
0.31 ± 0.19
7.42 ± 3.67
2.58 ± 1.36
6.79 ± 3.14
1.57 ± 0.42
15.05 ± 7.72
5.01 ± 4.16
YHZT DT
0.72 ± 0.65
4.53 ± 2.62
4.52 ± 2.05
8.60 ± 4.01
3.40 ± 1.37
30.09 ± 22.46
4.58 ± 2.45
YHZT DP
0.53 ± 0.22
9.87 ± 4.64
4.60 ± 4.53
14.24 ± 6.99
2.63 ± 1.24
14.99 ± 11.72
2.52 ± 1.03
Bcin
YHZT OL
0.31 ± 0.19
21.57 ± 10.39
0.27 ± 0.05
10.56 ± 3.63
0.43 ± 0.08
9.99 ± 4.03
25.76 ± 8.49
YHZT DT
ND
ND
ND
ND
ND
ND
ND
YHZT DP
0.50 ± 0.18
44.48 ± 19.09
0.45 ± 0.40
28.86 ± 13.06
0.59 ± 0.18
5.13 ± 6.78
6.54 ± 2.28
Thc
YHZT OL
0.31 ± 0.19
49.17 ± 17.76
1.94 ± 0.38
58.28 ± 22.30
1.72 ± 0.15
1.08 ± 0.66
0.38 ± 0.20
YHZT DT
0.72 ± 0.65
130.67 ± 66.39
1.68 ± 0.39
222.98 ± 96.04
2.30 ± 0.93
0.82 ± 0.43
0.34 ± 0.18
YHZT DP
0.56 ± 0.17
201.33 ± 114.79
2.49 ± 1.29
329.31 ± 188.70
2.08 ± 0.38
0.68 ± 0.48
0.18 ± 0.09
Bcol
YHZT OL
0.31 ± 0.19
4.30 ± 2.10
0.27 ± 0.05
2.16 ± 0.73
0.44 ± 0.08
15.68 ± 6.72
39.44 ± 11.44
YHZT DT
ND
ND
ND
ND
ND
ND
ND
YHZT DP
0.50 ± 0.18
8.58 ± 3.98
0.49 ± 0.49
5.74 ± 2.62
0.63 ± 0.14
11.99 ± 17.04
13.69 ± 4.75
, compared with oral liquid. ND, nondetected value.
