3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists

<div>Effect of compound <b>6</b> on TLR7-mediated innate cytokines expression. THP1 cells were treated with 40 <i>μ</i>M compound <b>6</b> for various periods (0–24 h). (a) TNF<i>α</i> and IL1<i>β</i> mRNA levels were determined using RT-PCR (a). GAPDH mRNA levels were used as an internal control. (b) PCR band intensities were measured using the Image J software. Bars represent the mean ± S.D. 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Journal of Chemistry

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Figure 5

Figure 5: 3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists 