3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists

Figure 7

LigPlot analysis of the compound 6-TLR7 complex. The oxygen of the carbonyl group of Gln354(B) is close to the thiazolone nitrogen of compound 6 (2.93 Å). Eight residues, including Tyr264 (B), Phe351(B), Val355(B), Tyr356(B), Phe408(B), Leu557(A), His558(A), and Thr586(A), participate in hydrophobic interactions with compound 6.