Synthesis, Characterization, and Biological Evaluation of Some Isoindole-1,3-(2H) Dione Derivatives

Table 1

List of some marketed drugs of isoindole-1,3(2H) dione derivatives and their analogues.

Structure	Name	Use
	Thalidomide; (RS) 2-(2,6-Dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione	Antineoplastic, antileprotic, FDA approved for multiple myeloma treatment, erythema nodosum leprosum (ENL)
	Pomalidomide (Actimid®); (RS)4-Amino2 (2,6-dioxopiperidin3yl) isoindoline-1,3-dione	Angiogenesis inhibitor, immunomodulator, FDA approved for multiple myeloma treatment
	Apremilast; (Otezla®)N-{2-[(1S)-1–(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1H-isoindol-4-yl} acetamide	Psoriasis and psoriatic arthritis
	Lenalidomide (Revlimid®); (RS)-3-(4-Amino-1-oxo-1, 3-dihydro-2H-isoindol-2-yl) piperidine-2, 6-dione	FDA approved for multiple myeloma
	Indoprofen; 2-[4-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl) phenyl] propanoic acid	Anti-inflammatory (withdrawn)
	Chlorthalidone; (RS)-2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide	Diuretic