Synthesis, Characterization, and Biological Evaluation of Some Isoindole-1,3-(2H) Dione Derivatives

Table 11

Effect of 72 hours of treatment with studied compounds on the cell cycle of Caco-2 cells.

Percentage of Caco-2 cells in each phase
Compound number	Concentration (μg/mL)	G1%	S%	G2/M%	Effect on cell cycle
Negative control	—	69.76	23.26	6.98	—
Compound 1	1000	52.09	37.47	10.44	Arrest on S and G2/M
Compound 2	500	50.8	40.52	8.68	Arrest on S and G2/M
Compound 3	500	48.39	43.13	8.48	Arrest on S and G2/M