Research Article
Synthesis, Characterization, and Biological Evaluation of Some Isoindole-1,3-(2H) Dione Derivatives
Table 12
Effect of 72 hours of treatment with studied compounds on the cell cycle of HCT-116 cells.
| | Percentage of HCT-116 cells in each phase | | Compound number | Concentration (μg/mL) | G1% | S% | G2/M% | Effect on cell cycle |
| | Negative control | — | 86.69 | 8.85 | 4.46 | — | | Compound 1 | 500 | 79.32 | 15.18 | 5.51 | Arrest on S | | Compound 2 | 125 | 72.5 | 18.4 | 9.1 | Arrest on S and G2/M | | Compound 3 | 125 | 65.48 | 20.22 | 14.3 | Arrest on S and G2/M |
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