Synthesis, Characterization, and Biological Evaluation of Some Isoindole-1,3-(2H) Dione Derivatives

Table 14

Cell death assay of HCT-116 cells untreated and treated with studied compounds.

Cell death assay in HCT-116 line
Compound number	Concentration (μg/mL)	R1% late apoptotic cells	R2% live cells	R3% early apoptotic cells	R4% necrotic cells
Negative control	—	16.64	76.96	6.22	0.32
Compound 1	500	36.95	34.29	3.57	26.28
Compound 2	125	42.5	35.2	10.5	11.8
Compound 3	125	17.14	33.71	0.64	49.52