Synthesis, Characterization, and Biological Evaluation of Some Isoindole-1,3-(2H) Dione Derivatives

Table 2

Calculated values for molecular weight (MW), TPSA, log, H-donor, and H-acceptor for compounds.

	Compound 1	Compound 2	Compound 3
Log	2.56	4.41	4.93
TPSA (A^2)	76.38	76.38	76.38
MW (g/mol)	295.29	433.07	610.88
Hydrogen acceptor	5	5	5
Hydrogen donor	1	1	1

TPSA value indicates good absorption after oral administration (TPSA < 140 Ų) and moderate ability to cross the blood-brain barrier (TPSA < 60 Ų) [36].