Synthesis, Characterization, and Biological Evaluation of Some Isoindole-1,3-(2H) Dione Derivatives

Table 3

Values of ADME properties of the studied compounds obtained using the in silico method.

ADME descriptor	Compound 1	Compound 2	Compound 3
HIA (human intestinal absorption) %	98.92	97.58	98.163
Caco-2 (nm/second)	21.0324	17.203	17.08
BBB (C brain/C blood)	0.456	1.959	1.82
Plasma_Protein_Binding (PPB%)	96.935	95.219	97.33
CYP_2C19_inhibition	Non	Non	Non
CYP_2C9_inhibition	Inhibitor	Inhibitor	Inhibitor
CYP_2D6_inhibition	Non	Non	Non
CYP_2D6_substrate	Non	Non	Non
CYP_3A4_inhibition	Non	Non	Non
CYP_3A4_substrate	Weakly	Weakly	Substrate
Pgp_inhibition	Non	Inhibitor	Inhibitor