Synthesis, Characterization, and Biological Evaluation of Some Isoindole-1,3-(2H) Dione Derivatives

Table 8

Antileishmanial effect of studied compounds (GI%) against Leishmania tropica.

Compound name	Antileishmanial effect of studied compounds (GI%)						IC50 μmol/mL
	75 μg/mL	125 μg/mL	250 μg/mL	500 μg/mL	1000 μg/mL	2000 μg/mL
Compound 1	50.2	62.81	64.52	66.74	69.12	76.75	0.25
Compound 2	59.85	67.78	69.18	73.15	77.8	85.75	0.111
Compound 3	64.5	72.86	74.42	79.31	82.65	95.12	0.0478
Glucantime	20.2	22.5	30.2	58.5	70.2	75.25	1.226

Compound 1: 0.001; compound 2: 0.001; compound 3: 0.0001; glucantime: 0.001.