Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study

<div>Inhibition by isoquercitrin (quercetin-3-O-glucoside) of SARS-CoV-2 virus main protease Mpro. The half-maximum inhibitory concentration (IC50) value was determined by nonlinear regression using 10 μM substrate and 1 μM enzyme with varying concentrations of isoquercitrin. The inhibitor constants (Ki) were determined using fluorescent peptide concentrations ranging from 0.31 μM to 80 μM, 2 μM of Mpro and two different inhibitor concentrations.</div>

Journal of Chemistry

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Figure 3: Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study

Figure 3 | Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study 