Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study

Table 3

Inhibition of SARS-CoV-2 main protease (M^pro) by isoquercitrin standard.

Compound	IC50 (µM)	Ki (µM)	Km (µM)	Kcat (s^−1)	Inhibition mechanism	SSQ	ΔAIC	ΔBIC
Isoquercitrin	63.22 ± 0.03	32 ± 5	25.8 ± 4.6	0.002 ± 0.0001	Competitive; Mixed	1.0; 1	0.4; 0	0; 0.8