A Novel Drug-Drug Salt of Naproxen and Vortioxetine: Synthesis, Characterization, and Solubility Study

Table 3

Measured solubility values of NAP, VOT, and NAP-VOT in water and pH 6.86 buffer solutions at 37°C.

Medium	Compound	Concentration (mmol/L)	Residue obtained in solubility experiment after 24 h
Water	NAP	21.44 × 10^−2	Stable
	VOT	15.00 × 10^−2	Stable
	NAP-VOT	27.69 × 10^−2	Stable
pH 6.86	NAP	8.53	Stable
	VOT	17.57 × 10^−2	Unstable
	NAP-VOT	48.34 × 10^−2	Stable