Preparation and Characterization of Patuletin-Loaded Chitosan Nanoparticles with Improved Selectivity and Safety Profiles for Anticancer Applications

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left"> </td><td class="align_center">W138 IC<sub>50 (<i>μ</i>M)</sub></td><td class="align_center">SI (MCF 7)</td><td class="align_center">SI (HCT 116)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">PT-CS-NP</td><td class="align_center">74.88</td><td class="align_center">31.07</td><td class="align_center">40.26</td></tr><tr><td class="align_left">PT</td><td class="align_center">102.19</td><td class="align_center">5.62</td><td class="align_center">12.85</td></tr><tr><td class="align_left">CS</td><td class="align_center">69.48</td><td class="align_center">7.85</td><td class="align_center">14.78</td></tr><tr><td class="align_left">Sorafenib</td><td class="align_center">71.96</td><td class="align_center">16.66</td><td class="align_center">9.88</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Antiproliferative activities against W138 cell lines and selectivity indices of PT-CS-NP, CS, and PT.</div>

Journal of Chemistry

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Table 3

Table 3: Preparation and Characterization of Patuletin-Loaded Chitosan Nanoparticles with Improved Selectivity and Safety Profiles for Anticancer Applications 

Table 3 | Preparation and Characterization of Patuletin-Loaded Chitosan Nanoparticles with Improved Selectivity and Safety Profiles for Anticancer Applications 