Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Structure</td><td class="align_center">MCF-7</td><td class="align_center">A549</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Zn-L<sub>1</sub></td><td class="align_center">7.48 ± 0.24</td><td class="align_center">8.15 ± 0.6</td></tr><tr><td class="align_left">Ni-L<sub>1</sub></td><td class="align_center">12.16 ± 0.79</td><td class="align_center">13.63 ± 0.91</td></tr><tr><td class="align_left">Zn-L<sub>2</sub></td><td class="align_center">8.37 ± 1.09</td><td class="align_center">9.07 ± 1.02</td></tr><tr><td class="align_left">Ni-L<sub>2</sub></td><td class="align_center">14.49 ± 1.4</td><td class="align_center">15.33 ± 1.85</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Comparison of cytotoxicity (IC<sub>50</sub> values based on <i>μ</i>M).</div>

Journal of Chemistry

tab4

Table 4

Table 4: Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes 

Table 4 | Synthesis and Evaluation of Cytotoxicity and Molecular Docking of New Symmetrical Macroacyclic Schiff Base Ligands and Their Ni(II) and Zn(II) Complexes 