In Vivo Antifungal Activity and Computational Studies of Some Azole Derivatives against Candida Albicans

Table 6

Metabolism and toxicity profile of all compounds.

Entry	CYP2D6	CYP3A4	Carcinogenicity	hERGinhibition
1	NS/NI	S/NI	NC	Weak
2	NS/NI	S/NI	NC	Weak
3	NS/NI	S/NI	NC	Weak
4	NS/NI	S/NI	NC	Weak
5	NS/NI	S/NI	NC	Weak
6	NS/NI	S/NI	NC	Weak
7	S/I	S/I	NC	Weak
8	S/I	S/I	NC	Weak
9	S/I	S/I	NC	Weak
10	S/I	S/I	NC	Weak
11	S/I	S/I	NC	Weak
12	NS/NI	S/I	NC	Weak
13	NS/NI	S/NI	NC	Weak
14	NS/NI	S/I	NC	Weak
15	NS/NI	S/I	NC	Weak
Fluconazole	NS/NI	S/NI	NC	Weak

^aHuman ether-a-go-go related gene, NS = nonsubstrate; NI = noninhibitor; S = substrate; I = inhibitor; NC = noncarcinogenic; C = carcinogenic.