Synthetic 2-Nitrocinnamates: Investigation of the Antifungal Action against Candida Species

Table 1

Evaluation of MIC (μg/mL; μM) of the esters derived from (E)-2-nitrocinnamic acid in the microdilution broth assay.

MIC (μg/mL; μM)
Compounds	C. albicans ATCC 90028		C. albicans LM 106		C. tropicalis ATCC 13803		C. tropicalis LM 31		C. parapsilosis LM 14		C. parapsilosis LM 02		C. krusei LM 13		C. krusei LM 08
1	512	2471.28	256	1235.64	128	617.82	128	617.82	128	617.82	128	617.82	256	1235.64	256	1235.64
2	256	1157.27	256	1157.27	128	578.63	128	578.63	128	578.63	128	578.63	128	578.63	128	578.63
3	512	2176.50	256	1088.25	256	1088.25	256	1088.25	512	2176.50	512	2176.50	512	2176.50	512	2176.50
4	128	513.52	128	513.52	128	513.52	128	513.52	128	513.52	128	513.52	128	513.52	128	513.52
5	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
6	128	509.47	128	509.47	128	509.47	128	509.47	128	509.47	256	1018.94	256	1018.94	256	1018.94
7	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
8	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
9	128	402.87	128	402.87	1024	3222.96	1024	3222.96	512	1611.48	1024	3222.96	1024	3222.96	256	805.74
10	128	356.17	128	356.17	256	712.35	128	356.17	128	356.17	+	+	+	+	+	+
11	128	408.55	128	408.55	1024	3268.43	+	+	+	+	+	+	512	1634.20	512	1634.20
12	+	+		+	+	+	+	+	+	+	+	+	+	+	+	+
13	128	383.99	128	383.99	128	383.99	128	383.99	256	767.98	256	767.98	256	767.98	256	767.98
14	128	390.99	128	390.99	128	390.99	128	390.99	128	390.99	256	781.98	256	781.98	256	781.98
Nystatin	64	69.10	256	276.42	128	138.21	256	276.42	256	276.42	256	276.42	64	69.10	128	138.21

(+) Presence of microbial growth. (−) Absence of microbial growth.