Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents

Table 1

Molecular and physical properties of synthesized compounds.

Compound no.	Compound name	Molecular formula	MW	Purity (%)	mp	Yield (%)
Compound 1	5-Methyl-3-[(4,5,6,7-tetrachloro-1,3-dioxo-1,3-dihydro-2H-isoindole-2-yl) methyl] hexanoic acid	C16H15Cl4NO4	427.11	98.50	177.6–180	A: 90; B: 92
Compound 2	5-Methyl-3-[(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-2H-isoindole-2-yl) methyl] hexanoic acid	C16H15Br4NO4	604.91	99.91	212-212.6	A: 83; B: 86
Compound 3	{1-[(1,3-Dioxo-1,3-dihydro-2H-isoindole-2-yl) methyl] cyclohexyl} acetic acid	C17H19NO4	301.34	99.18	151-152	A: 80; B: 84
Compound 4	{1-[(4,5,6,7-Tetrachloro-1,3-dioxo-1,3-dihydro-2H-isoindole-2-yl) methyl] cyclohexyl} acetic acid	C17H15Cl4NO4	439.12	99.99	218–218.4	A: 70; B: 75
Compound 5	{1-[(4,5,6,7-Tetrabromo-1,3-dioxo-1,3-dihydro-2H-isoindole-2-yl) methyl] cyclohexyl} acetic acid	C17H15Br4NO4	616.92	95.90	241.5–243	A: 77; B: 80