Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents

Table 2

In vitro antimicrobial activity of synthesized compounds against Staphylococcus aureus.

Zone of inhibition on Staphylococcus aureus (mm)
Conc. μg/mL	3200 μg/mL	1600 μg/mL	800 μg/mL	400 μg/mL	200 μg/mL	100 μg/mL
Pregabalin	—	—	—	—	—	—
Gabapentin	—	—	—	—	—	—
Compound 1	20	18.67	18	14.34	12	9.67
Compound 2	21.67	20	19.67	19.34	18.67	16.34
Compound 3	16	12	0	0	0	0
Compound 4	19	17.33	16.5	15.67	14.67	11.67
Compound 5	20	18.34	17.67	17	16.67	14.67
Gentamicin Sulfate	26	25	24	22.34	21.34	19.34