Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents

Table 3

In vitro antimicrobial activity of synthesized compounds against Escherichia coli.

Zone of inhibition on E. coli (mm)
Conc. μg/mL	3200 μg/mL	1600 μg/mL	800 μg/mL	400 μg/mL	200 μg/mL	100 μg/mL
Pregabalin	—	—	—	—	—	—
Gabapentin	—	—	—	—	—	—
Compound 1	23	20	18	16	14	13
Compound 2	24	23	22.67	22.34	21.67	20.34
Compound 3	14.34	13.34	12.37	11.67	11	10.34
Compound 4	15	13.67	13	11.67	11.34	10.67
Compound 5	16	15	14	13.67	13.34	12.67
Gentamicin Sulfate	21	20	17	13	0	0