Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents

Table 5

Antiproliferative effect of studied compounds on the Caco-2 cell line.

Compound number	Antiproliferative effect % on Caco-2 cell line						IC50 (μmol/mL)
Compound 1	Conc. μg/mL	500	250	125	75	25	0.2724
	GI %	74.58	73.08	65.37	0	0
Compound 2	Conc. μg/mL	125	75	35	10	5	0.000639
	GI %	72.9	72.66	69.25	58.12	52.25
Compound 3	Conc. μg/mL	1000	500	250	125	75	2.0845
	GI %	69.9	39	19	0	0
Compound 4	Conc. μg/mL	100	50	25	12.5	10	0.1450
	GI %	72.67	44.2	8.67	0	0

GI%: percentage of growth inhibition.