Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents

Table 6

Antiproliferative effect of studied compounds on the HCT-116 cell line.

Compound number	Antiproliferative effect % on HCT-116 cell line						IC50 (μmol/mL)
Compound 1	Conc. μg/mL	500	250	125	75	25	0.412
	GI %	55.774	52.102	49.392	48.308	30.462
Compound 2	Conc. μg/mL	1000	500	250	125	75	0.413
	GI %	33.133∗	45.384∗	50.02	49.855	49.189
Compound 3	Conc. μg/mL	1000	500	250	125	75	>3.39
	GI %	48.322	22.858	15.685	7.255	1.683
Compound 4	Conc. μg/mL	100	50	25	12.5	10	0.228
	GI %	49.558	47.406	24.692	7.236	0