Synthesis, Characterization, and Pharmacokinetic Studies of Thiazolidine-2,4-Dione Derivatives

Table 1

IUPAC name and structure of TZDs (C1–C5) derivatives.

Ligand	IUPAC name	Structure
C1	(Z)-N-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)phenyl)-2-(piperaszin-1-yl)acetamide
C2	(Z)-N-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)phenyl)-2-(4-methylpiperazin-1-yl)acetamide
C3	(Z)-N-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)phenyl)-2-(4-(phenylsulfonyl)piperazin-1-yl)acetamide
C4	(Z)-N-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)phenyl)-2-morpholinoacetamide
C5	(Z)-N-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)phenyl)-2-(piperidin-1-yl)acetamide