Synthesis, Characterization, and Pharmacokinetic Studies of Thiazolidine-2,4-Dione Derivatives

Table 2

The physicochemical property of TZDs derivatives calculated with swissADME database.

Ligands	Molecular formula	MW (g/mol)	nHA	nAHA	F. Csp^3	nRB	nHBA	nHBD	MR	TPSA (A^2)
C1	C16H18N4O3S	346.40	24	6	0.31	5	5	3	104.08	115.84
C2	C17H20N4O3S	360.43	25	6	0.35	5	5	2	108.99	107.05
C3	C22H22N4O5S2	486.56	33	12	0.23	7	7	2	136.79	149.57
C4	C16H17N3O4S	347.39	24	6	0.31	5	5	2	98.45	113.04
C5	C17H19N3O3S	345.42	24	6	0.35	5	4	2	102.17	103.81

Molecular weight: M. W, No. heavy atom: nHA, No. arom. heavy atom: nAHA, No. of sp³ hybridized carbon out of total carbon count: F. Csp³, No. rotatable bonds: nRB, No. H-bond acceptors: nHBA, No. H-bond donors: nHBD, Molar refractivity: MR, topological polar surface area: TPSA.