Synthesis, Characterization, and Pharmacokinetic Studies of Thiazolidine-2,4-Dione Derivatives

Table 3

Lipophilicity and water solubility of TZDs (C1–C5) derivatives.

Ligands	Lipophilicity	Water solubility
	Consensus log o/w	Log S(ESOL)	Solubility class	Log S(all)	Solubility class	Log S(SILICOS-IT)	Solubility class
C1	0.68	−2.33	Soluble	−2.79	Soluble	−4.06	Moderately soluble
C2	0.93	−2.71	Soluble	−3.10	Soluble	−3.73	Soluble
C3	1.57	−3.96	Soluble	−4.83	Moderately soluble	−5.66	Moderately soluble
C4	0.97	−2.52	Soluble	−3.04	Soluble	−3.75	Soluble
C5	1.82	−3.28	Soluble	−4.11	Moderately soluble	−4.29	Moderately soluble