Synthesis, Characterization, and Pharmacokinetic Studies of Thiazolidine-2,4-Dione Derivatives

Table 4

Pharmacokinetics of TZDs (C1–C5) derivatives calculated with SwissADME database.

Ligands	GI absorption	Bioavailability score	BBB permeant	-gp substrate	CYP1A2 inhibitors	CYP2C19 inhibitors	CYP2C9 inhibitors	CYP2D6 inhibitors	CYP3A4 inhibitors
C1	High	0.55	No	Yes	No	No	No	No	No
C2	High	0.55	No	Yes	No	No	No	No	No
C3	Low	0.55	No	Yes	No	No	Yes	No	No
C4	High	0.55	No	Yes	No	No	No	No	No
C5	High	0.55	No	Yes	Yes	Yes	No	No	No