Identifying USP1 Inhibitors with Allosteric Effect on Its Triple Catalytic Center through Virtual Screening

Figure 4

The binding modes of Z28551960/USP1 (a), Z423064076_USP1 (b), Z1037335610_USP1 (c), and Z1129923146_USP1 (d) to the USP1 protein. The white cartoon represents the USP1 protein, the yellow cartoon represents ubiquitin, and the sticks represent small molecules. The yellow dashed lines indicate hydrogen bonds, and the green dashed lines indicate Pi-Pi conjugation.

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(b)

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(d)