| 
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| Model | Mono/cosubstrates | Objectives | References | 
| 
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| AP | Wastewater | To simulate and optimize the operating parameters, including OLR, temperature, effects of H2 addition/pH value, and recycle ratios to maximize biogas production | [122] | 
| Waste sludge and expired yogurt | Prediction of kinetic parameters and simulation of codigestion | [112] | 
| Cattle manure and dairy milk processing waste | To simulate dairy milk process plant and investment profitability of biogas use in drying milk | [120] | 
| Cow dung and food waste | To simulate codigestion to predict the amount of biogas production | [116] | 
| Potato stem and milk whey | Optimization of organic load and evaluation of technoeconomic assessment | [114] | 
| Pulp mill primary and secondary sludge | To evaluate the potential of bioenergy production and optimization of mixing ratios | [123] | 
| VOC emissions | To optimize and simulate biogas production | [124] | 
| Palm oil mill effluent | To optimize and simulate process parameters to produce maximum methane | [125] | 
| Cow manure | Modeling and optimization of biogas and hydrogen production and effects of process parameters | [126] | 
| Municipal solid waste | To optimize and analyze methane production | [127] | 
| Food waste and primary sludge | To model biogas production, combined heat and power, economic analysis, and optimization of mixing ratios | [128] | 
| 
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| ADM1 | Food waste | Effect of hydraulic retention time (HRT), C/N ratio, and changes in feed composition on the biogas production | [129] | 
| Municipal solid waste | To optimize and simulate the OLRs, pH, and other parameters | [111] | 
| Solid waste | To investigate the effects of pH and VFA on biogas production | [130] | 
| Primary sludge | To simulate the dynamic properties of a primary sludge digester in a full-scale digester | [131] | 
| Pig manure with silages, thin stillage, and glycerine phase | To optimize and simulate codigestion and kinetic parameters to predict biogas production | [132] | 
| 
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| ADM1xp | Lactate | To assess the effect of adding lactic acid into ADM1 in influencing the prediction potential of the model | [133] | 
| Food waste and waste-activated sludge | To model, predict, and simulate operational performances and biological behavior of monodigestion/codigestion | [134] | 
| Dairy manure spent and mushroom substrate | To model and predict pH and the kinetics of biogas production to optimize the substrate ratio and HRT | [135] | 
| 
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| ADM1-PID | Waste-activated sludge and corn silage | To simulate and optimize the mixing ratio to achieve maximum methane production | [136] | 
| Diluted dairy manure kitchen wastes | To optimize the mixing ratio of codigestion and HRT and to evaluate hydrolysis kinetics to enhance methane production | [137] | 
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