Selective mPGES-1 Inhibitor Ameliorated Adjuvant-Induced Arthritis in the Rat Model

<div>Analysis of MPO-0144 side effects. All data were collected from AIA rats, which had been treated with MPO-0144 for 14 days. (a) Representative images of gastric lesions in the corpus of the stomach following different treatments, and the blue-colored arrows indicated the indomethacin-induced gastric hemorrhagic regions (top). Ulcerative score of the indomethacin-treated group = 3.5 ± 0.6, which are means ± SD of <i>n</i> = 8 animals (bottom); (b) level of biomarkers representing liver, kidney, and heart toxicities. Values are means ± SD of <i>n</i> = 8 animals for each group. Statistically significant values were compared using one-way ANOVA and Dunnett’s post hoc test. <span class="nowrap"><svg height="10.7395pt" id="M8" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g><g 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22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,55.606,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the vehicle group. All statistics were performed using GraphPad Prism 5 statistical software (GraphPad Software Inc., CA, USA).</div>

Journal of Chemistry

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Figure 4

Figure 4: Selective mPGES-1 Inhibitor Ameliorated Adjuvant-Induced Arthritis in the Rat Model 