Novel Phytosomal Formulation of Emblica officinalis Extracts with Its In Vivo Nootropic Potential in Rats: Optimization and Development by Box-Behnken Design
Table 2
Box-Behnken design matrix with actual values and respective entrapment efficiencies.
BBD run
Factor A
Factor B
Factor C
Response
Phospholipid: drug ratio (%w/w) (drug = 1 gm)
Temperature (°C)
Time (h)
Entrapment efficiency (%)
1
3
50
1
82.3 ± 1.10
2
2
40
1
80.3 ± 1.60
3
2
50
2
85.8 ± 0.72
4
2
40
3
83.3 ± 0.89
5
2
50
2
85.6 ± 0.93
6
1
50
3
84.3 ± 0.74
7
2
50
2
86.9 ± 0.91
8
1
50
1
80.1 ± 1.30
9
3
40
2
83.2 ± 0.78
10
3
50
3
84.8 ± 0.92
11
1
60
2
87.3 ± 1.23
12
3
60
2
90.3 ± 1.16
13
2
60
1
82.7 ± 0.91
14
2
50
2
86.3 ± 0.88
15
1
40
2
83.6 ± 1.20
16
2
60
3
89.9 ± 1.75
17
2
50
2
86.9 ± 1.98
The information is shown as mean ± SD values (n = 3).
