Novel Phytosomal Formulation of Emblica officinalis Extracts with Its In Vivo Nootropic Potential in Rats: Optimization and Development by Box-Behnken Design

Table 6

Results of pharmacokinetic study after oral administration of EOE and EOP formulation.

Pharmacokinetic parameters	Treatment
	EOE (250 mg/kg)	EOP (∼250 mg/kg)
(μg/ml)	2.72 ± 0.147	5.14 ± 0.164
(h)	3.04 ± 0.004	6.1 ± 0.005
AUC0-t (μg/ml  h)	29.91 ± 0.18	77.68 ± 0.15
AUC0-∞ (μg/ml  h)	31.84 ± 0.11	86.42 ± 0.17
t1/2ka (h)	1.017 ± 0.22	4.08 ± 0.27
V/F (mg/kg)/(μg/ml)	125.48 ± 0.029	37.55 ± 0.035
CL/F (mg/kg)/(μg/ml)/h	15.70 ± 0.24	5.79 ± 0.17

The information is shown as mean ± SD values (n = 6).