Therapeutic Potential of Withaferin-A and Propolis Combinational Drug Therapy for Breast Cancer: An In Vivo Interpretation for Validating the Antiproliferative Efficacy and Ameliorative Potential in Benzo[a]pyrene-Induced Breast Metastasis

Table 1

Pharmacodynamic effect of Withaferin-A along with propolis on the level of glycoproteins in the plasma of naïve and interventional rats.

Particulars	Group I (control)	Group II (benzo[a]pyrene-induced)	Group III (withaferin-A-treated)	Group IV (propolis-treated)	Group V (both withaferin-A- and propolis-treated)	Group VI (control rats treated with withaferin-A- and propolis-treated)
Hexose	193.65 ± 17.76	257.49 ± 23.09a^#	219.66 ± 20.12b^@	216.22 ± 20.846b	193.65 ± 17.76	193.88 ± 20.68
Hexosamine	30.76 ± 2.81	45.71 ± 4.10a^#	38.45 ± 3.59b^@	41.41 ± 4.01b	30.76 ± 2.81	31.01 ± 2.86
Sialic acid	42.61 ± 4.02	67.72 ± 6.26a^#	53.31 ± 5.12b^#	58.61 ± 5.67b^@	44.61 ± 4.02	43.12 ± 4.45

Each value is expressed as mean ± SD for six rats in each group. Units: mg/dl. a: as compared with Group I. b: as compared with Group II. Statistical significance: ; ^@; ^#.