Enhancing Intranasal Delivery and Bioavailability of Dihydroergotamine Utilizing Chitosan Nanoparticles

Table 1

Physicochemical properties of chitosan nanoparticles prepared with different loading of DHE.

DHE theoretical loading in chitosan nanoparticles (%)	Particle size (nm)	Loading (%)	Encapsulation efficiency (%)	Polydiversity index	Zeta-potential (mV)
20	395 ± 59	19 ± 2.6	95 ± 13	0.438 ± 0.031	+26.5 ± 1.9
30	402 ± 65	25 ± 5	83 ± 16.7	0.436 ± 0.007	+30.3 ± 1.3
40	689 ± 67	33.7 ± 6	84 ± 15	0.69 ± 0.164	+35 ± 2.93