NUDT15 Haplotypes and Diplotypes Predict Thiopurine-Induced Leukopenia and the Influence of Prolonged Exposure to Azathioprine on Hematologic Indices in Patients with Inflammatory Bowel Diseases

Figure 1

Influence of prolonged exposure to AZA on hematologic indices in different NUDT15 genotypes: (a) changes of WBC count in the wild-type group and the mutant group. Significant difference between the mutant group and wild-type group at 1st month (, Student’s t-test). (b) Changes of MCV in the wild-type group and mutant group. Significant differences between the baseline and 6th and 12th months. ( and , respectively, ANOVA and Bonferroni correction adjusted values). (c) Changes of PLT count in the wild-type group and mutant group. ^∗Significant difference between the mutant group and wild-type group at 12th month (, Mann–Whitney U-test).

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