Research Article

NUDT15 Haplotypes and Diplotypes Predict Thiopurine-Induced Leukopenia and the Influence of Prolonged Exposure to Azathioprine on Hematologic Indices in Patients with Inflammatory Bowel Diseases

Figure 2

AZA final and tolerance dosage among patients with different NUDT15 genotypes: (a) final dosage between NUDT15 wild-type cases and mutant cases. Significant difference between the mutant group and wild-type group (1.02 (0.35–2.0) mg·kg−1·d−1 vs. 1.36 (0.56–2.5) mg·kg−1·d−1, , Mann–Whitney U-test). (b) Final dosage among individuals with different diplotypes. 1/1 (1.36 (0.56–2.50) mg·kg−1·d−1), 1/2 (1.25 (0.56–1.67) mg·kg−1·d−1), 1/3 (0.94 (0.41–2.0) mg·kg−1·d−1), 1/6 (1.07 (0.89–1.25) mg·kg−1·d−1), 3/3 (1.06 mg·kg−1·d−1), and 3/5 (0.35 mg·kg−1·d−1). Significant difference between the NUDT15 1/1 group and NUDT15 3/5 group (). (c) Tolerance dosage between wild-type cases and mutant cases (1.15 (0.83–2.50) mg·kg−1·d−1 vs. 1.04 (0.56–2.0) mg·kg−1·d−1, ). (d) Tolerance dosage among individuals with different diplotypes (). 1/1 (1.15 (0.83–2.50) mg·kg−1·d−1), 1/2 (1.31 (0.56–1.54) mg·kg−1·d−1), 1/3 (1.00 (0.86–2.00) mg·kg−1·d−1), and 1/6 (1.07 (0.89–1.25) mg·kg−1·d−1).
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