NUDT15 Haplotypes and Diplotypes Predict Thiopurine-Induced Leukopenia and the Influence of Prolonged Exposure to Azathioprine on Hematologic Indices in Patients with Inflammatory Bowel Diseases

Table 2

NUDT15 haplotypes and AZA-induced leukopenia.

Genotype		Total patients	Patients with AZA (%)	Prevalence of leukopenia (%)		Allele	Allele frequency (%)		Odds ratios (95% CI)
c.415C > T	CC	143 (73.7)	60 (75)	9 (15)	8 × 10 ^−^5	C	86.9	7 × 10 ^−^5	6.16 (2.33–16.28)
	CT	45 (23.2)	19 (23.75)	11 (57.9)		T	13.1
	TT	6 (3.1)	1 (1.25)	1 (100)
c.36_37ins GGAGTC	−/−	168 (86.6)	69 (86.25)	14 (20.3)	0.006	—	93.1	0.008	5.70 (1.58–20.62)
	−/ins	26 (13.4)	11 (13.75)	7 (63.7)		Ins	6.9
c.52G > A	GG	187 (96.4)	79 (98.75)	20 (25.3)	0.262	G	99.4	0.262	3.88 (2.98–5.05)
	GA	7 (3.6)	1 (1.25)	1 (100)		A	0.6

The values in bold in the table are less than 0.05.