NUDT15 Haplotypes and Diplotypes Predict Thiopurine-Induced Leukopenia and the Influence of Prolonged Exposure to Azathioprine on Hematologic Indices in Patients with Inflammatory Bowel Diseases
Table 3
Associations of NUDT15 haplotypes with grades and phases of leukopenia.
Group
NUDT15 c.415C > T, n
NUDT15 c.36_37 insGGAGTC, n
NUDT15 c.52G > A, n
CC
CT
TT
−/−
−/ins
GG
GA
Total, n
60
19
1
8×10−5
69
11
0.006
79
1
0.262
Normal, n
51
8
0
55
4
59
0
Leukopenia grade, n
9
11
1
2×10−4
14
ccc7
0.006
20
1
0.125
Grade 1
6
5
0
0.025
6
5
0.003
11
0
Grade 2
3
6
0
0.002
7
2
0.177
8
1
Grade 3
0
0
1
0.15
1
0
1
1
0
Leukopenia phase, n
9
11
1
5×10−4
14
7
0.015
20
c1
0.123
Early
1
4
1
8×10−4
4
2
0.09
5
1
Middle
2
2
0
0.115
3
1
0.288
4
0
Late
6
5
0
0.025
7
4
0.016
11
0
values were adjusted by Bonferroni correction. The values in bold in the table are the most statistically significant in the subgroup analysis.
