NUDT15 Haplotypes and Diplotypes Predict Thiopurine-Induced Leukopenia and the Influence of Prolonged Exposure to Azathioprine on Hematologic Indices in Patients with Inflammatory Bowel Diseases

Table 4

Associations of NUDT15 diplotypes with grades and phases of leukopenia.

Group	1/1	1/2		1/3		3/3 + 3/5
Total, n	58	9		9		2
Normal, n	49	2	0.0004	6	0.345	0	0.031
Leukopenia grades, n	9	7	0.0007	3	0.056	2	0.0019
Grade 1	6	5	0.001	0		0
Grade 2	3	2	0.036	3		1^†	0.075
Grade 3	0	0		0		1^‡	0.02
Leukopenia phases, n	9	7	0.0005				0.0026
Early	1	2	0.012	1		2	0.039
Middle	2	1	0.16	1		0
Late	6	4	0.005	1		0

^†NUDT15 3/5; ^‡NUDT15 3/3; values were adjusted by Bonferroni correction. The values in bold in the table are the most statistically significant in the subgroup analysis.